Dimethylformamide → HCID 178427455, compound

Participants

Reaction Steps

A mixture of 3.4 g of 4-methyl-N-[4-(4-cyanophenoxy)butyl]benzenesulfonamlde (Example 53), 1.3 g of sodium azide, 1.5 g of ammonium chloride, and 25 ml of dimethylformamide is stirred at 120°-130° C. (oil bath) for 16 hours. The reaction mixture is added to 200 ml of water and the resultant solution then acidified to pH 4-5 with acetic acid. The precipitate that forms is collected, washed with water, dried and recrystallized from boiling ethanol. Cooling gives the pure compound, m.p. 180°-182° C.; yield, 2.4 g.

Provenance & Evidence