4-Toluenesulfonyl chloride → HCID 67598288, compound

Participants

Reaction Steps

To a solution of 7.2 g of 4-[4-(acetamido)phenylthio]butaneamine (Example 70) in 100 ml of dichloromethane containing 8 ml of triethylamine is added 6.2 g of 4-methylbenzenesulfonyl chloride. The mixture is then stirred under reflux for six hours. The solvents are removed in vacuo. The residue is triturated with 2 portions of 100 ml of water. The insoluble portion is recrystallized from aqueous ethanol. Initially, the product precipitates as an oil, but after standing, crystals are obtained, m.p. 104°-105° C.; yield, 6.6 g.

Provenance & Evidence