4-Bromobenzoyl chloride → HCID 67693663, compound

Participants

Reaction Steps

A solution of 2.9 g of 5-[4-(1H-imidazol-1-yl)phenoxy]pentaneamine (Example 27) in 150 ml of dichloromethane and 100 ml 1N NaOH are combined and stirred vigorously as 2.8 g of 4-bromobenzoyl chloride is added. The reaction mixture is stirred at room temperature for 20 hours, the dichloromethane layer separated and dried over Na2SO4. The dichloromethane solution is diluted with 200 ml of hexane, and the solution concentrated to turbidity. Cooling the mixture at room temperature gives the desired product as white crystals, m.p. 150°-151° C.; yield, 1.4 g.

Provenance & Evidence