Sodium Hydroxide → HCID 67693808, compound

Participants

Reaction Steps

A mixture of 2.04 g of 3-[4-(1H-imidazol-1-yl)phenoxy]propanamine dihydrochloride (Example 92) in 70 ml of methylene chloride is treated with 21 ml of 1N NaOH followed by 1.54 g of 4-bromobenzoyl chloride with stirring at room temperature for 18 hours. Additional methylene chloride and 5 ml of 1N NaOH is added and the organic layer separated, washed with water and filtered. The organic layer is evaporated in vacuo to a residue which is washed with ether and dried to give 1.3 g of off-white solid, m.p. 183°-185° C.

Provenance & Evidence