Sodium Acetate → HCID 67587774, compound

Participants

Reaction Steps

The compound can be prepared from N-[6-(4-benzoylphenoxy)-hexyl]-maleamic acid from Example 11 by reacting with acetic acid and sodium acetate according to the method described in Example 2. The desired maleimide was isolated as its monohydrate by flash column chromatography. Mp 84--6° C. (Found: C, 72.78; H, 6.28; N, 3.58%. C23H23NO3, H2O requires C, 73.19; H, 6.65; N, 3.69%). H.p.l.c. 100%. FAB ms 378 (MH+). 1H-n.m.r. (CDCl3) δ 6.9 (2H, m, aromatic), 6.6 (2H, d, CH=CH), 3.9 (2H, m, CH2), 3.5 (2H, m, CH2), 1.8 (2H, m, CH2), 1.6 (2H, m, CH2), 1.5 (2H, m, CH2), 1.3 (2H, m, CH2). λmax (CH2Cl2) 286 nm, ε 16590.

Provenance & Evidence