反应详情

温度

100 °C

2-Chloroisonicotinonitrile (1.0 g) and dipropylamine (10 mL) were placed in a sealed heavy wall tube and heated to 100° C. for 18 h. The mixture was removed from heat and cooled to room temperature. The dipropylamine was removed under reduced pressure and the residue chromatographed on silica gel using 2% ethyl acetate in hexanes as eluent to give 1.06 g of the title compound: MS (ESI+) for C12H17N3 m/z 204.1 (M+H)+.

1. customThe mixture was removed
2. temperaturefrom heat
3. temperaturecooled to room temperature
4. customThe dipropylamine was removed under reduced pressure
5. customthe residue chromatographed on silica gel using 2% ethyl acetate in hexanes as eluent