HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 8-(t-Butoxycarbonyl)amino-octanoic acid methyl-butyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 8-(((Tert-butoxy)carbonyl)amino)octanoic acid | HCID 546215 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | N-methylbutylamine hydrochloride | HCID 6337757 | — |
| Reactant | HCID 178526939 | HCID 178526939 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-(t-Butoxycarbonyl)amino-octanoic acid methyl-butyl-amide | HCID 53721969 | — |
Reaction Steps
Combine 8-(t-butoxycarbonyl)amino-octanoic acid (1.28 g, 5 mmol), N-methylmorpholine (1.2 mL, 10 mmol), 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride salt (0.95 g, 5.0 mmol), methyl-butyl amine hydrochloride salt (5.0 mmol), and 4-hydroxybenztriazole hydrate (0.05 g) in dichloromethane (20 mL). After 4 hours, add water and extract with ethyl acetate. Dry the organic layer over MgSO4 and evaporate in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05877202 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-d97eb11b1d854ecfac8ea4633b8374a2 |
| Source note | uspto-grants-1999_03 |