Hydrochloric Acid → HCID 53694139, compound

Participants

Reaction Steps

6 mg of tetrakistriphenylphosphine palladium, 7 mg of triphenylphosphine and 65 mg of sodium 2-ethylhexanoate were added to a solution of 104 mg of allyl 2-benzyl-2-(1-benzylindol-6-yl)acetate, as obtained in Example 65, in 5 ml of methylene chloride, and the resulting mixture was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was acidified by the addition of a 3% aqueous solution of hydrochloric acid, followed by extraction with ethyl acetate. The extract was washed with water and dried over anhydrous sodium sulfate, and then the solvent was removed by evaporation under reduced pressure. The resulting residue was subjected to column chromatography using 5 g of silica gel with a 1:1 v/v mixture of hexane and ethyl acetate as the eluent, to yield 61 mg of the title compound as a solid material, melting at 148°-150° C.

Provenance & Evidence