Nitroethane → HCID 53843028, compound

HRID 1417535Notes

Reaction equation

HRID 1417535 reaction equation
[N+:1]([CH2:4][CH3:5])([O-:3])=[O:2].C(N)CCC.[Br:11][C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[CH:15]=O>C(O)C>[Br:11][C:12]1[CH:13]=[C:14]([CH:15]=[C:4]([N+:1]([O-:3])=[O:2])[CH3:5])[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]

Participants

5

Reactant 3

HCID 6587NitroethaneHCID 8007ButylamineHCID 986623-Bromo-4-methoxybenzaldehyde

Product 1

HCID 53843028HCID 53843028, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
95 °C

Procedure

Nitroethane (0.800 mL, 836 mg, 11.1 mmol) and n-butylamine (0.050 mL, 37 mg, 0.51 mmol) were added to a solution of 3-bromo-4-methoxybenzaldehyde (2.00 g, 9.30 mmol) in 2.0 mL of absolute ethanol. The solution was heated in a 95° C. oil bath for 8 h and then stirred overnight at room temperature. The ethanol was evaporated, the residue was stirred with 12 mL of 8% ether in hexane, and the supernatant was decanted. The undissolved material was stirred with 12 mL of 8% ether in hexane, and sufficient toluene was added to bring it into solution at 60° C. The crystals which separated at room temperature were recrystallized again from a solution of hexane (7 mL) and toluene (1.8 mL) at 55° C. cooled to room temperature to give 1-(3-bromo-4-methoxyphenyl)-2-nitropropene as 598 mg of yellow needles. All of the mother liquors were combined and evaporated, and the residue was purified by flash column chromatography on 85 g of silica gel eluting with 25% dichloromethane in hexane to give an additional 791 mg of 1-(3-bromo-4-methoxyphenyl)-2-nitropropene (total isolated yield of 55%). 1H NMR (400 MHz, CDCl3): δ 8.00 (s, 1H), 7.68 (d, 1H, J=2 Hz),7.40 (dd, 1H, J=9, 2 Hz),6.97(d, 1H, J=9Hz), 3.96 (s, 3H), 2.47 (s, 3H). Mass spectrum (NH3CI): m/e=272 (M+1).

Workup

  1. customThe ethanol was evaporated
  2. stirringthe residue was stirred with 12 mL of 8% ether in hexane
  3. customthe supernatant was decanted
  4. stirringThe undissolved material was stirred with 12 mL of 8% ether in hexane, and sufficient toluene
  5. additionwas added
  6. customat 60° C
  7. customThe crystals which separated at room temperature
  8. customwere recrystallized again from a solution of hexane (7 mL) and toluene (1.8 mL) at 55° C.
  9. temperaturecooled to room temperature

Sources & evidence

ORD record
ord-2c5be5ced0644bcf83f6cee86bbed5dd
Source dataset
uspto-grants-1999_03
Patent number
US05877191

Reaction notes

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