Hydrochloric Acid → HCID 86753767, compound

Participants

Reaction Steps

(5R,6S,7S)-6-(4-Fluorophenyl)-3-(5-cyano-2-isopropoxyphenyl)-1-oxaspiro[4.4]non-3-ene-7-carboxylic acid methyl ester(128 mg, 0.294 mmol) was taken up in THF(2 mL) and methanol (2 mL) and treated with 2.5N NaOH (0.4 mL, 1.0 mmol) for 6 hours at room temperature. 2N Hydrochloric acid (5 mL) was then added, and the product extracted with ethyl acetate (2×30 mL). The combined extracts were washed with saturated brine solution, dried (MgSO4), and evaporated to afford the title compound; yield 124 mg.

Provenance & Evidence