Sodium borohydride → HCID 67572167, compound

Participants

Reaction Steps

To a solution of 2-bromo-4-nitro-methylthioanisole (450 mg, 1.81 mmol) in 45 mL of MeOH was added a suspension of copper(11) acetate (85 mg, 0.47 mmol) in 9 mL of MeOH. Sodium borohydride (300 mg, 7.9 mmol) was added as a solid over 0.5 h. The reaction was diluted with Et2O, washed with NaHCO3, dried with Na2SO4, filtered, and conc. to give 387 mg of the title compound. MS:m/e=218 (M+1) 1H NMR (400 Mhz, CDCl3): δ 2.35 (s, 3H), 6.62 (dd, 1H), 6.94 (d, 1H), 7.08 (d, 1H)

Provenance & Evidence