Hydrochloric Acid → HCID 67672163, compound

HRID 1417551Notes

Reaction equation

C[O:2][C:3]([C@H:5]1[CH2:30][CH2:29][C@:7]2([O:11][CH2:10][C@H:9]([C:12]3[CH:17]=[C:16]([N:18]4[CH:22]=[CH:21][N:20]=[C:19]4[C:23]([F:26])([F:25])[F:24])[CH:15]=[CH:14][C:13]=3[O:27][CH3:28])[CH2:8]2)[C@@H:6]1[C:31]1[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=1)=[O:4].[OH-].[Na+].Cl>C(O)C.O>[F:37][C:34]1[CH:35]=[CH:36][C:31]([C@H:6]2[C@@H:5]([C:3]([OH:4])=[O:2])[CH2:30][CH2:29][C@@:7]32[O:11][CH2:10][C@H:9]([C:12]2[CH:17]=[C:16]([N:18]4[CH:22]=[CH:21][N:20]=[C:19]4[C:23]([F:26])([F:25])[F:24])[CH:15]=[CH:14][C:13]=2[O:27][CH3:28])[CH2:8]3)=[CH:32][CH:33]=1

Participants

Conditions

Temperature: 0 °C

Procedure

To an ice cold solution of 40 mg (0.077 mmol) (3S,5R,6S,7S)-6-(4-fluorophenyl)-3-(2-methoxy-5-(2-trifluoromethylimidazol-1-yl)phenyl)-1-oxaspiro[4.4]nonane-7-carboxylic acid methyl ester (from Example 70) in 1.0 mL of ethanol and 0.20 mL of water was added 0.050 mL of 2.5N aqueous NaOH. The mixture was stirred at 0° C., then warmed slowly to RT overnight. After neutralizing with 0.065 mL of 2N aqueous HCl, the mixture was partitioned between 25 mL of ethyl acetate and 25 mL of brine. The layers were separated and the organic layer was dried over sodium sulfate and evaporated to give 40 mg of title compound as a colorless syrup. Mass spectrum (NH3/CI): m/z=505.0 (M+1).

Workup

temperaturewarmed slowly to RT overnight
customthe mixture was partitioned between 25 mL of ethyl acetate and 25 mL of brine
customThe layers were separated
dry with materialthe organic layer was dried over sodium sulfate
customevaporated

Sources & evidence

ORD record: ord-734052d1bf674d6f8fb9fffa361c78b1
Source dataset: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05877191

Reaction notes

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