m-Anisoyl chloride → HCID 18627805, compound

HRID 1417569Notes

Reaction equation

HRID 1417569 reaction equation
[NH2:1][CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.[C:11](Cl)(=[O:20])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1>>[C:11]([NH:1][CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1)(=[O:20])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1

Participants

3

Reactant 2

HCID 74374m-Anisoyl chlorideHCID 123445(+-)-1-Aminoindan

Product 1

HCID 18627805HCID 18627805, compound

Procedure

The title compound was prepared from (rac)-1-aminoindan (1.6 g, 12.3 mmole) and m-anisoyl chloride (1.9 g, 13.54 mmole) as in Ex. 46; crystallization from EtOAc:hexane gave 2:0 g (7.2 mmole, 59w) white solid, mp: 140° C.

Workup

  1. customcrystallization from EtOAc
  2. customhexane gave 2

Sources & evidence

ORD record
ord-9652dfebfac34fdd9882ea135aa9298f
Source dataset
uspto-grants-1999_03
Patent number
US05877221

Reaction notes

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