HCID 86753797, compound → HCID 86753796, compound

Participants

Reaction Steps

To Compound (33a) (40 mg, 0.087 mmol) dissolved in 4.0 ml of ethanol was added 12 mg of 10% palladium-carbon, and the mixture stirred at room temperature for 2 hours under hydrogen atmosphere. After filtration for removing palladium-carbon, the reaction was concentrated under reduced pressure. The residue was purified by a silica gel column chromatography (silica gel 2.0 g; chloroform:methanol:water=9:1:0.1-7:3:0.3). The fraction containing the desired compound was concentrated under reduced pressure. The residue was dissolved in a small amount of THF. To the solution was added ether gradually, and the precipitate formed was filtered to give Compound (34a) (17 mg, 53%) as a powder.

Provenance & Evidence