Succinic anhydride → HCID 86753800, compound

Participants

Reaction Steps

To a solution of Compound (33a) (38 mg, 0.08 mmol) in dry pyridine (0.4 ml) was added 16 mg (0.16 mmol) of succinic anhydride, and the mixture stirred for 1 hour at room temperature. Ice-water was added to the reaction, followed by extraction with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the resulting residue was purified by silica gel column chromatography (silica gel 2.0 g; chloroform:methanol:water=9:1:0.1) to give 46 mg (100%) of Compound (33c).

Provenance & Evidence