反应详情

To Compound (46a) (30 mg, 0.063 mmol) dissolved in 4.0 ml of methanol was added 6 mg of 10% palladium-carbon, and the mixture stirred under hydrogen atmosphere for 1 hour at room temperature. After the palladium-carbon was removed by filtration, the filtrate was concentrated under reduced pressure. The residue was crystallized from diethyl ether, and recrystallized from diethyl ether-methanol to give 16 mg (48%) of Compound (47a).

1. customAfter the palladium-carbon was removed by filtration
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue was crystallized from diethyl ether
4. customrecrystallized from diethyl ether-methanol