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HRID1417631

反应详情

EQUATION

反应方程式

HRID 1417631 的结构方程式

REACTANTS

反应物

1
结构：C[C@H]1CC[C@H]2C(C)(C)[C@@H](O)CC[C@]23Oc2c(c(OCc4ccccc4)cc4c2CN(C(=O)OC(C)(C)C)C4=O)C[C@]13C
HCID86753807

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1CC[C@H]2C(C)(C)[C@@H](O)CC[C@]23Oc2c(c(O)cc4c2CN(C(=O)OC(C)(C)C)C4=O)C[C@]13C
HCID86753839

未命名化合物

收率 91%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[C].[Pd]
催化剂HCID178418390

未命名化合物

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of Compound (39a) (Step-1 in Example 44) (303 mg, 0.53 mmol) in 10 ml of methanol containing 1% water was added 30 mg of 10% palladium-carbon, followed by catalytic reduction under atomospheric pressure for 2.5 hours. After the catalyst was removed by filtration, the filtrate was concentrated under reduced pressure. The residue was purified by a column chromatography (silica gel 5 g; ethyl acetate) to give 234 mg (91%) of Compound (55a).

WORKUP

后处理

  1. customAfter the catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by a column chromatography (silica gel 5 g; ethyl acetate)