HCID 86753845, compound → HCID 86753844, compound

Participants

Reaction Steps

To Compound (66a) (28 mg, 0.06 mmol) dissolved in 15 ml of methanol containing 10% water was added 20 mg of 10% palladium-carbon, followed by catalytic reduction for 2.5 hours. After the palladium-carbon was removed by filtration, the filtrate was concentrated under reduced pressure. The residue was purified by a silica gel column chromatography (silica gel 5 g; ethyl acetate: methanol=19:1) and by crystallization from diethyl ether-n-hexane to give 17 mg (74%) of Compound (67a). Melting point: 280°-285° C. (decomp.) Elemental analysis for C24H33NO4.5/2 H2O Calcd.: C, 64.84%; H, 8.62%; N, 3.15% Found: C, 64.53%; H, 8.94%; N, 3.28%

Provenance & Evidence