Dimethyl Sulfoxide → N4-cyclohexyl-N4,6-dimethyl-N2-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

HRID 141769Notes

Reaction equation

HRID 141769 reaction equation
[CH3:1][NH:2][CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1.[CH3:41][S:42]([CH3:43])=[O:44].[F:9][C:10]([F:11])([F:12])[S:13]([O:14][c:15]1[c:16]2[c:17]([n:18][c:19]([NH:21][c:22]3[cH:23][cH:24][c:25](-[n:28]4[c:29]([CH3:33])[n:30][cH:31][cH:32]4)[cH:26][cH:27]3)[n:20]1)[CH2:34][CH2:35][N:36]([CH3:38])[CH2:37]2)(=[O:39])=[O:40]>>[CH3:1][N:2]([CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1)[c:15]1[c:16]2[c:17]([n:18][c:19]([NH:21][c:22]3[cH:23][cH:24][c:25](-[n:28]4[c:29]([CH3:33])[n:30][cH:31][cH:32]4)[cH:26][cH:27]3)[n:20]1)[CH2:34][CH2:35][N:36]([CH3:38])[CH2:37]2

Participants

4

Reactant 3

HCID 679Dimethyl SulfoxideHCID 7514N-MethylcyclohexylamineHCID 593337246-methyl-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl trifluoromethanesulfonate

Product 1

HCID 46200351N4-cyclohexyl-N4,6-dimethyl-N2-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

Sources & evidence

ORD record
ord-81f2b77643fc40b6870988d6eefaa0ec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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