Hydrochloric Acid → HCID 86753779, compound

Participants

Reaction Steps

258 mg (0.5 mmol) of ethyl (E)-4-[[2-[4-(1-adamantyl)-3-hydroxyphenyl]ethenyl]]benzoate, 105 mg (2.5 mmol) of lithium hydroxide and 10 ml of THF were introduced into a round-bottomed flask. The reaction medium was stirred at room temperature for 12 hours, poured into water, neutralized with hydrochloric acid and extracted with ethyl ether. The organic phase was separated out after settling had taken place, dried over magnesium sulfate and evaporated. The residue obtained was triturated from a mixture of dichloromethane and hexane, filtered and dried. 95 mg (51%) of the expected acid, having a melting point of 334°-5° C., were recovered.

Provenance & Evidence