反应详情

Following the method of Preparation 3, 0.179 g (0.577 mmol) of 4-(4-acetyl-2,6-dimethoxyphenoxy)-butanoic acid, ethyl ester is treated with potassium carbonate, producing an off-white solid. Recrystallization from ethyl acetate/hexane gives 4-(4-acetyl-2,6-dimethoxyphenoxy)butanoic acid as white crystals (0.14 g, 88%): m.p. 122°-24° C.; IR (KBr) 1735, 1660 cm-1 ; 1H-NMR (CDCl3) is consistent with the desired product; MS (FAB) m/e 283 (M+ +H). Analysis calculated for C14H18O6 : C, 59.57; H, 6.43; O, 34.01. Found: C, 59.34; H, 6.40; O, 34.26.

1. customproducing an off-white solid
2. customRecrystallization from ethyl acetate/hexane