Potassium Carbonate → 4-[4-(3-Hydroxypropyl)phenoxy]butanoic acid

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Reaction Steps

After the method of Preparation 3, 4.13 g (15.51 mmol) of 4-[4-(3-hydroxypropyl)phenoxy]butanoic acid, ethyl ester is saponified with potassium carbonate to produce a solid. This is recrystallized from an ethyl acetate-hexane mixture giving 2.45 (66%) of 4-[4-(3-hydroxypropyl)phenoxy]butanoic acid as white crystals: m.p. 92°-94° C.; IR (KBr) 3420 (br.), 1710 cm-1 ; 1H-NMR (CDCl3) is consistent with the desired product; MS (CI) m/e 239 (M+ +H). Analysis calculated for C13H18O4 : C, 65.53; H, 7.61; O, 26.86. Found: C, 65.75; H, 7.87; O, 26.38.

Provenance & Evidence