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Dichloromethane methanol → 1-[2-(Isochroman-1-yl)ethyl]-4-(3-methoxyphenyl)piperazine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane methanol | HCID 21226129 | — |
| 反応物 | 1-[2-(Isochroman-1-yl)ethyl]-4-(2-methoxyphenyl)piperazine dihydrochloride monohydrate | HCID 23288951 | — |
| 生成物 | 1-[2-(Isochroman-1-yl)ethyl]-4-(3-methoxyphenyl)piperazine dihydrochloride | HCID 23288913 | — |
反応手順
Following the general procedure of EXAMPLE 1 and making non-critical variations but using 1-(3-methoxyphenyl)piperazine dihydrochloride (XI, 0.5173 g, 1.95 mmol) in place of 1-(2-chlorophenyl)piperazine dihydrochloride (XI), the title compound is obtained (chromatography using methanol/dichloromethane, 1/99), mp 189.5°-193°; MS (m/z) 352; IR (mineral oil) 2373, 1460, 1512, 1048, 748 and 1291 cm-1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05877317 |
| 出典データセット | uspto-grants-1999_03 |
| ORD ID | ord-35661b7f8bdc461888df1a1163516cc4 |
| 出典メモ | uspto-grants-1999_03 |