HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-1-(2-chloroethyl)isochroman → 1-[2-(6-Chloroisochroman-1-yl)ethyl]-4-(4-methoxyphenyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-1-(2-chloroethyl)isochroman | HCID 23288787 | — |
| Reactant | 1-[2-(Isochroman-1-yl)ethyl]-4-(2-methoxyphenyl)piperazine dihydrochloride monohydrate | HCID 23288951 | — |
| Product | 1-[2-(6-Chloroisochroman-1-yl)ethyl]-4-(4-methoxyphenyl)piperazine dihydrochloride | HCID 23288911 | — |
Reaction Steps
Following the general procedure of EXAMPLE 1 and making non-critical variations but using 6-chloro-1-(2-chloroethyl)isochroman (LXIV, 0.2315 g, 0.972 mmol) and 1-(4-methoxyphenyl)piperazine dihydrochloride (XI, 0.3772 g, 1.00 mmol), the title compound is obtained, mp 203.5°-208°; MS (m/z) 386; IR (mineral oil) 1512, 2388, 1485, 1261, 1118 and 1105 cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05877317 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-2dc94ca63ead4ca7a04c1e1221e90d09 |
| Source note | uspto-grants-1999_03 |