Methyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate → Methyl 2-(3-hydroxypropyl)benzoate

Participants

Reaction Steps

Step 2--A mixture of methyl o-(1-hydroxy-2-propyn-3-yl)benzoate (CXIX, 5.91 g) in methanol (60 ml) is hydrogenated at 40 psi hydrogen for 9 hrs using a total of 900 mg. Palladium on carbon (10%) is added in equal portions three times during the course of the reaction. The reaction is filtered and concentrated to give the saturated ester, methyl o-(1-hydroxyprop-3-yl)benzoate (CXXI).

Provenance & Evidence