HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Piperazin-1-yl)benzene-1-sulfonamide → (S)-(-)-3-Bromo-4-[4-[2-(6-bromoisochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Piperazin-1-yl)benzene-1-sulfonamide | HCID 901897 | — |
| Reactant | 2-(6-Bromoisochroman-1-yl)ethanol | HCID 23288830 | — |
| Reactant | 3-Bromo-4-(piperazin-1-yl)-benzenesulfonamide hydrochloride | HCID 23288838 | — |
| Reactant | 1-(2-Bromo-4-methoxyphenyl)piperazine | HCID 23288928 | — |
| Product | (S)-(-)-3-Bromo-4-[4-[2-(6-bromoisochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide | HCID 54523419 | — |
Reaction Steps
Following the general procedure of EXAMPLE 49 and making non-critical variations, 2-(6-bromoisochroman-1-yl)ethanol (LXXIX, 0.399 g) and 3-bromo-4-(piperazin-1-yl)-benzenesulfonamide hydrochloride (VIII, Chart C, 0.544 g; prepared by the method of EXAMPLE 37 but using 4-(piperazin-1-yl)benzenesulfonamide (IV) in place of 1-(4-methoxyphenyl)piperazine) are combined to give the title compound; mp 206°-208°; MS (m/z) 557 and 559; IR (mineral oil) 1165, 1338, 1450, 616, 1586 and 731 cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05877317 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-68e3fa093a0b4493b2e1b6cedc59944a |
| Source note | uspto-grants-1999_03 |