HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Piperazin-1-yl)benzene-1-sulfonamide → (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]-cis-3,5-dimethylpiperazin-1-yl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Piperazin-1-yl)benzene-1-sulfonamide | HCID 901897 | — |
| Reactant | rel-(2R,6S)-2,6-dimethylpiperazine | HCID 6950261 | — |
| Reactant | 2-(3,4-dihydro-1H-2-benzopyran-1-yl)acetic acid | HCID 13308864 | — |
| Reactant | 4-(3,5-Dimethylpiperazin-1-yl)benzamide | HCID 23288921 | — |
| Reactant | 1-(2-Chloroethyl)-4-methyl-isochroman | HCID 23288938 | — |
| Product | (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]-cis-3,5-dimethylpiperazin-1-yl]benzamide | HCID 15487843 | — |
Reaction Steps
Following the general procedure of EXAMPLE 48 and making non-critical variations (-)-isochromanylacetic acid (LXI, EXAMPLE 45, 0.346 g) and 4-(3,5-dimethylpiperazin-1-yl)benzamide [(IV), 0.462 g; prepared from 4-fluorobenzamide (III) and cis-2,6-dimethylpiperazine (II, Aldrich) by the procedure of EXAMPLE 47, Step 1] gives the title compound, mp 206°-207°; MS (m/z) 393; IR (mineral oil) 1640, 1607, 1246, 3383, 1402, 1395, 1422, 1112 and 1332 cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05877317 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-2f643efe2821488f83ca49dfa690eff7 |
| Source note | uspto-grants-1999_03 |