4-(Piperazin-1-yl)benzene-1-sulfonamide → 4-[4-((R)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]-benzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	4-(Piperazin-1-yl)benzene-1-sulfonamide	HCID 901897	—
Reactant	(-)-2-(Isochroman-1-yl)ethanol	HCID 14141298	—
Product	4-[4-((R)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]-benzenesulfonamide	HCID 10811059	—

Reaction Steps

Following the general procedure for EXAMPLE 49 and making non-critical variations 2-(isochroman-1-yl)ethanol (LXXIX, (+)-enantiomer, 0.6045 g) and 4-(piperazin-1-yl)benezenesulfonamide (IV, 0.9824 g ) are combined to give the title compound, mp 189°-190°; MS (m/z) 401; [α]D +48 (c 0.877, DMF); IR (mineral oil) 1162, 1594, 1150, 1101, 614 cm-1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05877317
Source dataset	uspto-grants-1999_03
ORD ID	ord-4519fa53bcd748e285998a20c54ec11d
Source note	uspto-grants-1999_03