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4-(Piperazin-1-yl)benzene-1-sulfonamide → (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Piperazin-1-yl)benzene-1-sulfonamide | HCID 901897 | — |
| 反応物 | rel-(2R,6S)-2,6-dimethylpiperazine | HCID 6950261 | — |
| 反応物 | (-)-2-(Isochroman-1-yl)ethanol | HCID 14141298 | — |
| 反応物 | 4-(Homopiperazin-1-yl)benzenesulfonamide | HCID 17792895 | — |
| 反応物 | 1-(2-Chloroethyl)-4-methyl-isochroman | HCID 23288938 | — |
| 生成物 | (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzenesulfonamide | HCID 53677310 | — |
反応手順
Following the general procedure for EXAMPLE 48 and making non-critical variations (-)-2-(isochroman-1-yl)ethanol (LXXIX) and 4-(homopiperazin-1-yl)benzenesulfonamide (IV; prepared from 4-fluorobenzenesulfonamide (III) and homopiperazine (II, Aldrich) by the method of EXAMPLE 47 Step 1) give the title compound, MS (m/z) 415; [α]D -50° (c 0.9996, methylene chloride); IR (mineral oil) 1153, 1595, 1102, 1511 and 1316 cm-1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05877317 |
| 出典データセット | uspto-grants-1999_03 |
| ORD ID | ord-db9a0d708eda4df8a049838f1fa50145 |
| 出典メモ | uspto-grants-1999_03 |