HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexahydro-1,4-diazepine → (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzamide methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexahydro-1,4-diazepine | HCID 68163 | — |
| Reactant | 4-Fluorobenzamide | HCID 71572 | — |
| Reactant | 4-(Piperazin-1-yl)benzene-1-sulfonamide | HCID 901897 | — |
| Reactant | rel-(2R,6S)-2,6-dimethylpiperazine | HCID 6950261 | — |
| Reactant | (-)-2-(Isochroman-1-yl)ethanol | HCID 14141298 | — |
| Reactant | 4-(Homopiperazin-1-yl)benzamide | HCID 28410931 | — |
| Reactant | N-Methyl-(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide N-Methyl-4-fluorobenzenesulfonamide | HCID 86753846 | — |
| Product | (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzamide methanesulfonate | HCID 86753847 | — |
Reaction Steps
Following the general procedure for EXAMPLE 49 and making non-critical variations (-)-2-(isochroman-1-yl)ethanol (LXXIX, 0.394 g) and 4-(homopiperazin-1-yl)benzamide (IV; 0.601 g prepared by the method of EXAMPLE 47, Step 1 from 4-fluorobenzamide, III, and homopiperazine, II) are combined to give the title compound, mp 163.75°-165°; MS (m/z) 379; [α]D -41° (c, 0.975, DMF); IR(mineral oil) 1609, 1043, 1662, 1167 and 1216 cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05877317 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-e68cdfcc45d54cc0aa5e138216c234c0 |
| Source note | uspto-grants-1999_03 |