m-Toluidine → HCID 53765283, compound

HRID 1417977Notes

Reaction equation

HRID 1417977 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[CH:3]=1.[CH3:16][C:17]1[CH:18]=[C:19]([CH:21]=[CH:22][CH:23]=1)[NH2:20]>>[CH3:15][C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][CH:12]=1)[NH:8][C:4]1[CH:3]=[C:2]([NH:20][C:19]2[CH:21]=[CH:22][CH:23]=[C:17]([CH3:16])[CH:18]=2)[N:7]=[CH:6][N:5]=1

Participants

3

Reactant 2

HCID 7934m-ToluidineHCID 51046229HCID 51046229, compound

Product 1

HCID 53765283HCID 53765283, compoundYield 25%

Procedure

Using an analogous procedure to that described in Example 2, 6-chloro-4-(3'-methylanilino)pyrimidine was reacted with 3-methylaniline to give 4,6-di-(3'-methylanilino)pyrimidine in 25% yield, m.p. 242°-244° C.;

Sources & evidence

ORD record
ord-345cc61caaa948d9ae1a7c4566c601ea
Source dataset
uspto-grants-1999_03
Patent number
US05880130

Reaction notes

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