Methyl(4-aminophenoxy)acetate → 4-(3'-Chloro-4'-fluoroanilino)-6-(4'-methoxycarbonylmethoxyanilino)pyrimidine

Participants

Reaction Steps

Using an analogous reaction procedure to that described in Example 6, 6-chloro-4-(3'-chloro-4'-fluoroanilino)pyrimidine (0.258 g) was reacted with 4-methoxycarbonylmethoxyaniline (0.195 g). The reaction product was chromatographed on silica and precipitated from a mixture of methylene chloride, methanol and hexane to give 4-(3'-chloro-4'-fluoroanilino)-6-(4'-methoxycarbonylmethoxyanilino)pyrimidine in 26% yield, m.p. 191°-193° C.

Provenance & Evidence