4-(2-Methoxyethoxy)aniline → 4-(3'-Chloro-4'-fluoroanilino)-6-[4'-(2-methoxyethoxy)anilino]pyrimidine

Beteiligte Stoffe

Reaktionsschritte

Using an analogous reaction procedure to that described in Example 6, 6-chloro-4-(3'-chloro-4'-fluoroanilino)pyrimidine (0.258 g) was reacted with 4-(2-methoxyethoxy)aniline (0.206 g). The reaction product was chromatographed on silica and precipitated from a mixture of methylene chloride and hexane to give 4-(3'-chloro-4'-fluoroanilino)-6-[4'-(2-methoxyethoxy)anilino]pyrimidine in 49% yield, m.p. 208°-210° C.;

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