2-(4-aminophenoxy)-N,N-dimethylacetamide → HCID 70345732, compound

HRID 1417984Notes

Reaction equation

HRID 1417984 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[CH:3]=1.[CH3:16][N:17]([CH3:29])[C:18]([CH2:20][O:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][CH:23]=1)=[O:19]>>[CH3:15][C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][CH:12]=1)[NH:8][C:4]1[CH:3]=[C:2]([NH:26][C:25]2[CH:24]=[CH:23][C:22]([O:21][CH2:20][C:18](=[O:19])[N:17]([CH3:16])[CH3:29])=[CH:28][CH:27]=2)[N:7]=[CH:6][N:5]=1

Participants

3

Reactant 2

HCID 2355472-(4-aminophenoxy)-N,N-dimethylacetamideHCID 51046229HCID 51046229, compound

Product 1

HCID 70345732HCID 70345732, compoundYield 15%

Procedure

Using an analogous reaction procedure to that described in Example 6, 6-chloro-4-(3'-methylanilino)pyrimidine (0.410 g) was reacted with 4-(N,N-dimethylcarbamoylmethoxy)aniline (0.420 g). The product was chromatographed on silica and recrystallised from a mixture of methylene chloride and hexane to give 4-(3'-methylanilino)-6-[4'-(N,N-dimethylcarbamoylmethoxy)anilino]pyrimidine in 15% yield, m.p. 135°-138° C.;

Workup

  1. customan analogous reaction procedure to
  2. customThe product was chromatographed on silica
  3. customrecrystallised from a mixture of methylene chloride and hexane

Sources & evidence

ORD record
ord-3669c9d2539d4b75a1d309b1885a7e6b
Source dataset
uspto-grants-1999_03
Patent number
US05880130

Reaction notes

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