2-(4-aminophenoxy)acetamide → HCID 70187532, compound

HRID 1417986Notes

Reaction equation

HRID 1417986 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[C:16]([CH2:19][O:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][CH:22]=1)(=[O:18])[NH2:17]>>[C:16]([CH2:19][O:20][C:21]1[CH:27]=[CH:26][C:24]([NH:25][C:2]2[CH:7]=[C:6]([NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:23][CH:22]=1)(=[O:18])[NH2:17]

Participants

3

Reactant 2

HCID 30260062-(4-aminophenoxy)acetamideHCID 51046229HCID 51046229, compound

Product 1

HCID 70187532HCID 70187532, compoundYield 30%

Procedure

Using an analogous procedure to that described in Example 13, 4-chloro-6-(3'-methylanilino)pyrimidine (0.23 g) was reacted with 4-(carbamoylmethoxy)aniline to give 4-[4'-(carbamoylmethoxy)anilino]6-(3'-methylanilino)pyrimidine in 30% yield, m.p. 212°-215° C.;

Sources & evidence

ORD record
ord-d47c389894e440869ef064115a3a2fa9
Source dataset
uspto-grants-1999_03
Patent number
US05880130

Reaction notes

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