反应详情

Using an analogous reaction procedure to that described in Example 6, 6-chloro-4-(4'-hydroxyanilino)pyrimidine (3.2 g) was reacted with 3-methylaniline (5 ml). The product so obtained was triturated under methylene chloride. The solid so obtained was filtered off and extracted with hot water. On cooling a solid precipitated from the aqueous solution. The solid was extracted from the aqueous solution with ethyl acetate, washed with water and with brine, dried (MgSO4) and recrystallised from a mixture of ethyl acetate and hexane to give 4-(4'-hydroxyanilino)-6-(3'-methylanilino)pyrimidine (0.15 g), m.p. 242°-245° C.;

1. customan analogous reaction procedure to
2. customThe product so obtained
3. customwas triturated under methylene chloride
4. customThe solid so obtained
5. filtrationwas filtered off
6. extractionextracted with hot water
7. temperatureOn cooling a solid
8. customprecipitated from the aqueous solution
9. extractionThe solid was extracted from the aqueous solution with ethyl acetate
10. washwashed with water and with brine
11. dry with materialdried (MgSO4)
12. customrecrystallised from a mixture of ethyl acetate and hexane