HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenol → 4-(4-Hydroxyanilino)-6-chloropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Hydroxyanilino)-6-chloropyrimidine | HCID 18009128 | 76% |
Reaction Steps
A mixture of 4,6-dichloropyrimidine (3.0 g), 4-aminophenol (2.2 g) and triethylamine (6 ml) in ethanol.(50 ml) was refluxed for 2 hours. The product so obtained was recrystallised from a mixture of ethyl acetate and hexane to give 6-chloro-4-(4'-hydroxyanilino)pyrimidine in 76% yield, m.p. 241-244° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05880130 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-79faea1fd27c478ab1add66f871f0627 |
| Source note | uspto-grants-1999_03 |