HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-N,N-dimethyl-1-propanamine → 4-[3'-(3-Dimethylaminopropoxy)anilino]-6-(3'-methylanilino)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-N,N-dimethyl-1-propanamine | HCID 66960 | — |
| Reactant | HCID 54524025 | HCID 54524025 | — |
| Product | 4-[3'-(3-Dimethylaminopropoxy)anilino]-6-(3'-methylanilino)pyrimidine | HCID 70187549 | 16% |
Reaction Steps
Using an analogous procedure to that described in Example 27, 4-(3'-hydroxyanilino)-6-(3'-methylanilino)pyrimidine (0.5 g) was reacted with 3-dimethylaminopropyl chloride to give 4-[3'-(3-dimethylaminopropoxy)anilino]-6-(3'-methylanilino)pyrimidine in 16% yield, m.p. 142°-144° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05880130 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-fe87c7e40ae94bd1ac9ea562fa9c75fe |
| Source note | uspto-grants-1999_03 |