Ethyl 2-(4-aminophenoxy)acetate → HCID 70187132, compound

HRID 1417997Notes

Reaction equation

HRID 1417997 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:16][C:17]1[CH:29]=[CH:28][C:20]([O:21][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:19][CH:18]=1>>[CH2:26]([O:25][C:23]([CH2:22][O:21][C:20]1[CH:19]=[CH:18][C:17]([NH:16][C:2]2[CH:7]=[C:6]([NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:29][CH:28]=1)=[O:24])[CH3:27]

Participants

3

Reactant 2

HCID 412616Ethyl 2-(4-aminophenoxy)acetateHCID 51046229HCID 51046229, compound

Product 1

HCID 70187132HCID 70187132, compoundYield 33.1%

Procedure

Using an analogous reaction procedure to that described in Example 6, 4-chloro-6-(3'-methylanilino)pyrimidine (1.0 g) was reacted with ethyl 4-aminophenoxyacetate (1.0 g). The product so obtained was chromatographed on silica to give 4-[4'-(ethoxycarbonylmethoxy)anilino]6-(3'-methylanilino)pyrimidine (0.57 g).

Workup

  1. customan analogous reaction procedure to
  2. customThe product so obtained
  3. customwas chromatographed on silica

Sources & evidence

ORD record
ord-5371e07637ae45e0b35d7d2d00d6b054
Source dataset
uspto-grants-1999_03
Patent number
US05880130

Reaction notes

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