2-[(4-Aminophenyl)(methyl)amino]ethan-1-ol → 4-[3'-chloro-4'-fluoroanilino]6-[4'-{N-(2-hydroxyethyl)-N-methylamino}anilino]pyrimidine

HRID 1418001노트

반응식

HRID 1418001 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[C:11]([Cl:16])[CH:10]=2)[CH:3]=1.[OH:17][CH2:18][CH2:19][N:20]([C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][CH:23]=1)[CH3:21]>>[Cl:16][C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][C:12]=1[F:15])[NH:8][C:4]1[CH:3]=[C:2]([NH:26][C:25]2[CH:24]=[CH:23][C:22]([N:20]([CH2:19][CH2:18][OH:17])[CH3:21])=[CH:28][CH:27]=2)[N:7]=[CH:6][N:5]=1

참가 물질

3

반응물 2

HCID 136283162-[(4-Aminophenyl)(methyl)amino]ethan-1-olHCID 542586564-(3-Chloro-4-fluorophenylamino)-6-chloropyrimidine

생성물 1

HCID 703459434-[3'-chloro-4'-fluoroanilino]6-[4'-{N-(2-hydroxyethyl)-N-methylamino}anilino]pyrimidine수율 10%

실험 절차

Using an analogous reaction procedure to that described in Example 6, 6-chloro-4-(3'-chloro-4'-fluoroanilino)pyrimidine (0.258 g) was reacted with 4-[N-(2-hydroxyethyl)-N-methylamino]aniline (0.166 g). The product so obtained was recrystallised from a mixture of methylene chloride, methanol and hexane to give 4-[3'-chloro-4'-fluoroanilino]6-[4'-{N-(2-hydroxyethyl) -N-methylamino}anilino]pyrimidine in 10% yield;

후처리

  1. customan analogous reaction procedure to
  2. customThe product so obtained
  3. customwas recrystallised from a mixture of methylene chloride, methanol and hexane

출처 및 근거

ORD 기록
ord-490492b55a594811879af3989e005020
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05880130

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