Water → HCID 86753854, compound

Participants

Reaction Steps

A mixture of 6-(3'-methylanilino)-4-[3'-(ethoxycarbonylmethoxy) anilino]pyrimidine (0.10 g) and diethanolamine (0.06 g) in ethanol (7 ml) was heated at reflux for 72 hours. The mixture was cooled and water (20 ml) added. The ethanol was evaporated and the solid filtered off to give 4-(3'-{N,N-di-(2-hydroxyethyl)carbamoylmethoxy}anilino]6-(3'-methylanilino)pyrimidine in 39% yield, m.p. 112°-113° C.;

Provenance & Evidence