反应详情

17.4 g of tetra-butylammonium tribromide are added at room temperature to 7 g of 1-(2,4-dichlorophenyl)propan-1-one in solution in a mixture of 420 ml of methylene chloride and 140 ml of methanol. After 24 hours, the reaction mixture is concentrated under vacuum. The residue is taken up in water and extracted with ethyl acetate, the organic phase is dried with sodium sulphate and evaporated under vacuum and the residue is then purified on a column of silica gel with a 20/1 (v/v) mixture of cyclohexane and ethyl acetate as eluent, to obtain an oil.

1. concentrationthe reaction mixture is concentrated under vacuum
2. extractionextracted with ethyl acetate
3. dry with materialthe organic phase is dried with sodium sulphate
4. customevaporated under vacuum
5. customthe residue is then purified on a column of silica gel with a 20/1 (v/v) mixture of cyclohexane and ethyl acetate as eluent
6. customto obtain an oil