Hydrochloric Acid → HCID 68726321, compound

Participants

Reaction Steps

To a solution of TMCA (2.82 g, 20 mmole) in dry CH2Cl2 (150 ml) were added N-hydroxysuccinimide (2.3 g, 20 mmole) and DMAPE-carbodiimide.HCl (3.92 g, 20 mmole). The substance obtained was stirred for 15 hours at room temperature. To this mixture was added (CH3CH2)3N (4.5 ml), glycinamide.Hcl (2.2 g. 20 mmole) and dry DMF (100 ml), and stirred for 24 hours at room temperature. The solvents were stripped off under reduced pressure. The residue was purified by chromatography (SiO2, CHCl3 :MeOH 97:3) followed by successive crystallization from CH2Cl2 :hexane and EtOAc:hexane, to afford 1.1 g (5.6 mmole, 28%) of a white crystalline solid, m.p.: 176° C.

Provenance & Evidence