HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → Colchicine, N-deacetyl-10-thio-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Thiocolchicine | HCID 17648 | — |
| Product | Colchicine, N-deacetyl-10-thio- | HCID 17649 | — |
Reaction Steps
In the case of thiocolchicine, the hydrolysis with hydrohalogen acids or, more preferably, with sulfuric acid (20% H2SO4 --120 h) allows one to obtain N-deacetylthiocolchicine and 3-demethyl-N-deacetylthiocolchicine in essentially quantitative yields.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05880160 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-94da5a9aacf24451a17d6921eb1e6ef7 |
| Source note | uspto-grants-1999_03 |