Water → HCID 54135764, compound

Participants

Reaction Steps

Methyl 4-(4-chlorophenyl)-4-cyclopropyl-2-fluorobut-2-enoate prepared as described in Example 1 (0.91 g) in dry diethyl ether (20 ml) was added dropwise to a stirred suspension of lithium aluminium hydride (0.34 g) in dry diethyl ether (25 ml) at 0° C. Stirring was continued during 40 minutes, while the mixture warmed to room temperature. Water (4 ml) was added, and the mixture was extracted with diethyl ether (3×20 ml). The combined organic layers were washed with water (3×10 ml), dried and evaporated under reduced pressure. The residual oil was chromatographed on silica gel using diethyl ether/hexane (2:3) to yield 4-(4-chlorophenyl)-4-cyclopropyl-2-fluorobut-2-enol (0.61 g, 78%).

Provenance & Evidence