Water → HCID 53748107, compound

Participants

Reaction Steps

Acetyl chloride (1.2 ml) was slowly added to a stirred solution of 4-(4-chlorophenyl)-4-cyclopropyl-2-fluorobut-2-enol (Example 6) (0.51 g) in benzene (30 ml) and pyridine (0.24 ml) at 0° C. and stirring was continued for 24 hours while the mixture warmed to room temperature. Water (2 ml) was added, and the mixture was extracted with diethyl ether (3×20 ml). The combined organic layers were washed with water (3×10 ml), dried and evaporated under reduced pressure. The residual oil was chromatographed on silica gel using diethyl ether/hexane (1:4) to yield 4-(4-chlorophenyl)-4-cyclopropyl-2-fluorobut-2-enyl acetate (0.46 g, 78%).

Provenance & Evidence