Magnesium → 4-(4-Ethoxyphenyl)-2-fluoro-1-(4-fluoro-3-phenoxyphenyl)-4-methylpent-2-ene

Participants

Reaction Steps

The method of Example 16 was repeated using a Grignard reagent, prepared from 4-fluoro-3-phenoxyphenyl bromide (0.28 g), tetrahydrofuran (2 ml) and magnesium (20 mg), and 4-(4-ethoxyphenyl)-2-fluoro-4-methylpent-2-enyl acetate (Example 14) (60 mg). The residue after evaporation was purified by preparative thin layer chromatography (solvent: diethyl ether/hexane; 1:9) and then preparative high performance liquid chromatography (column: C18: solvent: 5% water in methanol; flow rate: 3 ml/min) to give the title compound (18 mg, 20%).

Provenance & Evidence