HuagongsheHuagongshe Chemistry Print Report · For research reference only
Magnesium → HCID 54005173, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | Benzene, 4-bromo-1-fluoro-2-phenoxy- | HCID 11076399 | — |
| Reactant | HCID 54398959 | HCID 54398959 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 54005173 | HCID 54005173 | 33% |
Reaction Steps
The method of Example 16 was repeated using a Grignard reagent, prepared from 4-fluoro-3-phenoxyphenyl bromide (0.4 g), tetrahydrofuran (4 ml) and magnesium (26 mg), and 2-fluoro4-methyl-4-(4-trifluoromethoxyphenyl)pent-2-enyl acetate (Example 15) (90 mg). The residue after evaporation was purified by preparative thin layer chromatography (solvent: diethyl ether/hexane; 1:9) to give the title compound (40 mg, 33%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05880162 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-ac4f4835ab1e4109ba237e0fbe658343 |
| Source note | uspto-grants-1999_03 |