HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(4-Cyanobenzyl)-5-(chloromethyl)imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(4-Cyanobenzyl)-5-hydroxymethyl-1H-imidazole | HCID 10198247 | — |
| Product | 1-(4-Cyanobenzyl)-5-(chloromethyl)imidazole | HCID 9795358 | — |
Reaction Steps
A solution of 1-(4-cyanobenzyl)-5-(hydroxymethyl)-imidazole (1.00 g, 4.70 mmol), in thionyl chloride (5 mL), was stirred at 70° C. for 16 hours. The solvent was evaporated in vacuo and the resulting solid suspended in CH2Cl2, collected by filtration and dried in vacuo. The material was sufficiently pure for use in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05880140 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-a8b7044f254e4d019ea9d1cad2a56c06 |
| Source note | uspto-grants-1999_03 |