2-t-Butyl-5-carbamoylaniline → N-(2-t-Butyl-5-carbamoylphenyl)-3-(2,4-dimethoxy-5-methoxycarbonylphenyl)octanamide

HRID 1418145Notes

Reaction equation

HRID 1418145 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([C:11]([O:13][CH3:14])=[O:12])=[CH:5][C:4]=1[CH:15]([CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:16][C:17]([OH:19])=O.[C:25]([C:29]1[CH:35]=[CH:34][C:33]([C:36](=[O:38])[NH2:37])=[CH:32][C:30]=1[NH2:31])([CH3:28])([CH3:27])[CH3:26]>C(Cl)Cl.C(OCC)C>[C:25]([C:29]1[CH:35]=[CH:34][C:33]([C:36](=[O:38])[NH2:37])=[CH:32][C:30]=1[NH:31][C:17](=[O:19])[CH2:16][CH:15]([C:4]1[CH:5]=[C:6]([C:11]([O:13][CH3:14])=[O:12])[C:7]([O:9][CH3:10])=[CH:8][C:3]=1[O:2][CH3:1])[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])([CH3:28])([CH3:26])[CH3:27]

Participants

4

Reactant 2

HCID 193486062-t-Butyl-5-carbamoylanilineHCID 19348732HCID 19348732, compound

Product 1

HCID 19348499N-(2-t-Butyl-5-carbamoylphenyl)-3-(2,4-dimethoxy-5-methoxycarbonylphenyl)octanamide

Reagents, catalysts & solvents 1

HCID 21881112Ethyl ether methylene chlorideSolvent

Procedure

Following a similar procedure to that described in Example 44, but using 3-(2,4-dimethoxy-5-methoxycarbonylphenyl)octanoic acid (prepared as described in Preparation 37) and 2-t-butyl-5-carbamoylaniline (prepared as described in Preparation 38), the title compound was obtained as crystals, melting at 101°-103° C. (from methylene chloride-diethyl ether).

Sources & evidence

ORD record
ord-567d043ac886467cabef4ebe8fba37ac
Source dataset
uspto-grants-1999_03
Patent number
US05880147

Reaction notes

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